NSAIDs are the most commonly prescribed class of drugs in the world and implicated in 20%
to 25% of all adverse drug reactions (ADRs), second only to antibiotics. 1, 2 ADRs are …

… These reactions appear to be IgE‐mediated. Patients suffering from single drug‐induced
anaphylaxis may take NSAIDs that were neither involved in the previous reactions nor …

… elicited by non-steroidal anti-inflammatory drugs (NSAIDs), discussing the … is expected to
be involved in these reactions, as well as the underlying … Single drug induced Usually none …

… urticaria, the prevalence of NSAID hypersensitivity might be even higher, affecting up to 20%
to 30%.1, 2 NSAID hypersensitivity reactions can be … NSAID single-drug-induced reactions …

… NSAIDs, otherwise normal subjects with urticaria induced by single or … NSAIDs, patients
with single drug-induced anaphylaxis, and patients with mixed respiratory/cutaneous reactions …

… and/or cutaneous reactions. Nonallergic NSAID reactions are known to be cross-reactive,
and therefore, patients who experience them can have a reaction to any NSAID that strongly …

… %) described a reaction to a single NSAID and 20 mentioned reactions with ≥2 different …
Single-drug-induced and cross-reactive NSAID-Hs were proven in 5 of 36 (14%) and 8 of 18 (44…

… Secondly, both aspirin and a COX-1–inhibiting NSAID (naproxen) induced cutaneous
urticarial reactions and simultaneously caused increased excretion of LTE 4 in the urine. …

… A total of 370 patients with a history of hypersensitivity reactions to NSAIDs … who were confirmed
as having NSAID hypersensitivity were included in this study. … Single drug induced None …

… Consequently, the number of adverse reactions owing to NSAID ingestion have paralleled
the increase in NSAID use and may account for up to … NSAID single-drug induced reactions. …