Native chemical ligation in the synthesis of internally modified oligonucleotide–peptide conjugates
F Diezmann, H Eberhard, O Seitz - Peptide Science, 2010 - Wiley Online Library
Peptide–oligonucleotide conjugates have frequently been synthesized to improve cellular
delivery of antisense or antigene compounds, to allow the immobilization of peptide and
protein conjugates on DNA arrays, or to decorate nucleic acid architectures with peptide
functions. In such applications, the site of conjugation is of little importance, and peptides
have predominantly been appended to one of the terminal ends of the oligonucleotide by
using an oxime‐, thioether‐, or disulfide‐linkage or native chemical ligation. We, herein …
delivery of antisense or antigene compounds, to allow the immobilization of peptide and
protein conjugates on DNA arrays, or to decorate nucleic acid architectures with peptide
functions. In such applications, the site of conjugation is of little importance, and peptides
have predominantly been appended to one of the terminal ends of the oligonucleotide by
using an oxime‐, thioether‐, or disulfide‐linkage or native chemical ligation. We, herein …
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