Natural product andrographolide alleviated APAP-induced liver fibrosis by activating Nrf2 antioxidant pathway
H Yan, Z Huang, Q Bai, Y Sheng, Z Hao, Z Wang, L Ji - Toxicology, 2018 - Elsevier
As a well-known analgesic drug, acetaminophen (APAP) is commonly used to relieve pain
for patients with chronic painful diseases. Our previous study has shown that long-term
ingestion of APAP caused liver fibrosis in mice. This study further investigated the critical
role of nuclear factor erythroid 2-related factor 2 (Nrf2) in regulating APAP-induced liver
fibrosis in mice and the anti-fibrotic effect of natural compound andrographolide (Andro). Our
results showed that hepatic collagen deposition and hepatic stellate cells (HSCs) activation …
for patients with chronic painful diseases. Our previous study has shown that long-term
ingestion of APAP caused liver fibrosis in mice. This study further investigated the critical
role of nuclear factor erythroid 2-related factor 2 (Nrf2) in regulating APAP-induced liver
fibrosis in mice and the anti-fibrotic effect of natural compound andrographolide (Andro). Our
results showed that hepatic collagen deposition and hepatic stellate cells (HSCs) activation …
Natural product andrographolide alleviated APAP-induced liver fibrosis by activating Nrf2 antioxidant pathway.
YHY Yan HongYu, HZL Huang ZhenLin… - 2018 - cabidigitallibrary.org
As a well-known analgesic drug, acetaminophen (APAP) is commonly used to relieve pain
for patients with chronic painful diseases. Our previous study has shown that long-term
ingestion of APAP caused liver fibrosis in mice. This study further investigated the critical
role of nuclear factor erythroid 2-related factor 2 (Nrf2) in regulating APAP-induced liver
fibrosis in mice and the anti-fibrotic effect of natural compound andrographolide (Andro). Our
results showed that hepatic collagen deposition and hepatic stellate cells (HSCs) activation …
for patients with chronic painful diseases. Our previous study has shown that long-term
ingestion of APAP caused liver fibrosis in mice. This study further investigated the critical
role of nuclear factor erythroid 2-related factor 2 (Nrf2) in regulating APAP-induced liver
fibrosis in mice and the anti-fibrotic effect of natural compound andrographolide (Andro). Our
results showed that hepatic collagen deposition and hepatic stellate cells (HSCs) activation …
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