This study investigated relationships between a microscale neural probe's size and shape
and its chronic reactive tissue response. Parylene-based probes were microfabricated with a
thick shank (48μm by 68μm) and an integrated thin lateral platform (5μm by 100μm, either
solid or one of three lattice sizes). Devices were implanted in rat cerebral cortex for 4 weeks
before immunostaining for neurons, astrocytes, microglia, fibronectin, laminin, and
neurofilament. While nonneuronal density (NND) generally increased and neuronal density …