Neurodevelopment of HIV-exposed uninfected infants born to women with perinatally acquired HIV in the United States

J Jao, D Kacanek, W Yu, PL Williams… - JAIDS Journal of …, 2020 - journals.lww.com
J Jao, D Kacanek, W Yu, PL Williams, K Patel, S Burchett, G Scott, EJ Abrams, RS Sperling…
JAIDS Journal of Acquired Immune Deficiency Syndromes, 2020journals.lww.com
Background: Lifelong HIV and antiretroviral therapy may confer neurodevelopmental risk on
the children of women with perinatally acquired HIV infection (PHIV). Setting: We analyzed
data from HIV-exposed uninfected (HEU) infants born to women with PHIV vs. non–
perinatally acquired HIV (NPHIV) enrolled in the Surveillance Monitoring for Antiretroviral
Therapy Toxicities (SMARTT) study. Methods: Using the Bayley Scales of Infant and Toddler
Development, third Ed.(Bayley-III), we compared neurodevelopmental outcomes at the age …
Abstract
Background:
Lifelong HIV and antiretroviral therapy may confer neurodevelopmental risk on the children of women with perinatally acquired HIV infection (PHIV).
Setting:
We analyzed data from HIV-exposed uninfected (HEU) infants born to women with PHIV vs. non–perinatally acquired HIV (NPHIV) enrolled in the Surveillance Monitoring for Antiretroviral Therapy Toxicities (SMARTT) study.
Methods:
Using the Bayley Scales of Infant and Toddler Development, third Ed.(Bayley-III), we compared neurodevelopmental outcomes at the age of 1 year in HEU infants born to women with PHIV vs. NPHIV. Those with valid Bayley-III data at the age of 1 year and a mother born after 1982 were included. Cognitive, language, and motor domains were assessed as continuous composite scores. Linear mixed effects models were fit to estimate the mean difference in Bayley-III scores between groups, adjusting for confounders.
Results:
Lippincott Williams & Wilkins
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