Neuroinflammation contributes to high salt intake-augmented neuronal activation and active coping responses to acute stress

TL Gilman, NC Mitchell, LC Daws… - International Journal of …, 2019 - academic.oup.com
High dietary salt intake increases risk of stress-related neuropsychiatric disorders. Here, we
explored the contribution of high dietary salt intake-induced neuroinflammation in key stress-
responsive brain regions, the hypothalamic paraventricular nucleus and basolateral
amygdala, in promoting exaggerated neuronal activation and coping behaviors in response
to acute psychogenic stress. Mice that underwent high dietary salt intake exhibited
increased active stress coping behaviors during and after an acute swim stress, and these …
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