[HTML][HTML] Neuropharmacology: A part for purines in pattern generation

FC Halliday, AJ Gibb - Current Biology, 1997 - cell.com
FC Halliday, AJ Gibb
Current Biology, 1997cell.com
… Ionic currents that contribute to the shaping of the firing patterns in this central pattern
generator have been characterized, and include a fast Na + current, a mixture of kinetically
similar Ca 2+ currents and several outward K + currents, including a transient K + current, Na +
-dependent and Ca 2+ -dependent K + currents and delayed rectifier K + currents [ … ] have
been able to measure quantitatively the effects of P1 and P2Y receptor activation on the ionic
currents in single isolated neurons, and upon the motor pattern in the intact Xenopus embryo …
Abstract
Purinergic transmission has been found to play a key role in the neural control of rhythmic swimming behaviour in Xenopus embryos; it may have similar importance in other vertebrate motor behaviours.
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