Neurotrophin delivery using nanotechnology

A Angelova, B Angelov, M Drechsler, S Lesieur - Drug discovery today, 2013 - Elsevier
… carriers favoring targeted delivery in specific brain areas and … targeted neurotrophin delivery
to localized areas in the CNS. … nanotechnologies for the production of neurotrophin delivery

From molecular to nanotechnology strategies for delivery of neurotrophins: emphasis on brain-derived neurotrophic factor (BDNF)

C Géral, A Angelova, S Lesieur - Pharmaceutics, 2013 - mdpi.com
… for delivery of brain-derived neurotrophic factor (BDNF), which is the most abundant neurotrophin
… Polymer-based carriers have provided sustained neurotrophin delivery, whereas lipid-…

[HTML][HTML] Brain-derived neurotrophic factor and its applications through nanosystem delivery

M Xia, T Zhao, X Wang, Y Li, Y Li, T Zheng… - Iranian Journal of …, 2021 - ncbi.nlm.nih.gov
… This paper reviewed the application of nano-drug delivery system loaded BDNF in the
treatment of various diseases, which provided a new scientific basis for the development and …

Dual and multi-drug delivery nanoparticles towards neuronal survival and synaptic repair

A Angelova, B Angelov - Neural regeneration research, 2017 - journals.lww.com
… disorders, the neurotrophin brain-derived neurotrophic factor (… Currently, BDNF is regarded
as the neurotrophic factor of … concepts in soft-matter nanotechnology towards preparation of …

Nanoformulation of brain‐derived neurotrophic factor with target receptor‐triggered‐release in the central nervous system

Y Jiang, JM Fay, CD Poon, N Vinod… - Advanced functional …, 2018 - Wiley Online Library
… The areas under the curve (AUC) from 0 to 30 min suggest that Nano-BDNF increases the
delivery of the neurotrophin in all brain regions, most notably in the olfactory bulb (≈6.7 times)…

BDNF gene delivery mediated by neuron-targeted nanoparticles is neuroprotective in peripheral nerve injury

CDF Lopes, NP Gonçalves, CP Gomes, MJ Saraiva… - Biomaterials, 2017 - Elsevier
delivery tools and application forms are being explored to attain the efficient local delivery
of neurotrophic … index (Pdi) and zeta potential using a Zetasizer Nano Zs (Malvern, UK). The …

Enhanced neurotrophin-3 bioactivity and release from a nanoparticle-loaded composite hydrogel

JC Stanwick, MD Baumann, MS Shoichet - Journal of controlled release, 2012 - Elsevier
… Toward the development of a drug delivery system for spinal cord injury, we explore the
influence of processing parameters on NT-3 stability, release kinetics, and bioactivity in the …

[HTML][HTML] Neurotrophic factors in Parkinson's disease: clinical trials, open challenges and nanoparticle-mediated delivery to the brain

O Bondarenko, M Saarma - Frontiers in Cellular Neuroscience, 2021 - frontiersin.org
delivery of NTFs in PD, and cover well-known NTFs as well as a new family of unconventional
NTFs consisting of mesencephalic astrocyte-derived neurotrophic … of nanotechnology to …

Targeted Brain Derived Neurotropic Factors (BDNF) Delivery across the Blood-Brain Barrier for Neuro-Protection Using Magnetic Nano Carriers: An In-Vitro Study

S Pilakka-Kanthikeel, VSR Atluri, V Sagar, SK Saxena… - PloS one, 2013 - journals.plos.org
… But these large neurotrophic protein molecules do not … pursued to deliver drugs across BBB
which include, the use of lipid … Some in-vivo strategies for delivering neurotrophic factors to …

Controlled delivery of brain derived neurotrophic factor and gold-nanoparticles from chitosan/TPP nanoparticles for tissue engineering applications

R Seyedebrahimi, S Razavi, J Varshosaz - Journal of Cluster Science, 2020 - Springer
neurotrophic factor (BDNF) is highly effective in the treatment of various diseases, and selected
for growth factor delivery … efficient delivery of BDNF and AuNPs, for tissue engineering. …