Nonreplication of association between μ‐opioid‐receptor gene (OPRM1) A118G polymorphism and substance dependence
P Franke, T Wang, MM Nöthen, M Knapp… - American journal of …, 2001 - Wiley Online Library
In the present investigation we hypothesized the A118G (Asn40Asp) polymorphism of the μ‐
opioid receptor gene (OPRM1) as a particular vulnerability factor for heroin and alcohol
dependence. Therefore, we tested this hypothesis in two independent large samples by two
different methods: a case‐control sample (comprising n= 287 heroin and n= 221 alcohol
study subjects versus n= 365 nondependent controls) and a family‐controlled sample of 111
parent‐offspring trios of heroin‐dependent study subjects and 75 parent‐offspring trios of …
opioid receptor gene (OPRM1) as a particular vulnerability factor for heroin and alcohol
dependence. Therefore, we tested this hypothesis in two independent large samples by two
different methods: a case‐control sample (comprising n= 287 heroin and n= 221 alcohol
study subjects versus n= 365 nondependent controls) and a family‐controlled sample of 111
parent‐offspring trios of heroin‐dependent study subjects and 75 parent‐offspring trios of …
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