Nox4-mediated ROS production is involved, but not essential for TGFβ-induced lens EMT leading to cataract
The reactive oxygen species (ROS) producing enzyme, NADPH oxidase 4 (Nox4), is
upregulated in response to TGFβ in lens epithelial cells in vitro, and its selective inhibition
was shown to block aspects of TGFβ-induced epithelial-mesenchymal transition (EMT). In
the present in situ study we validate the role (s) of Nox4 in TGFβ-induced lens EMT leading
to anterior subcapsular cataract (ASC) formation. Mice overexpressing TGFβ in the lens, that
develop ASC, were crossed to Nox4-deficient mice. When comparing mice overexpressing …
upregulated in response to TGFβ in lens epithelial cells in vitro, and its selective inhibition
was shown to block aspects of TGFβ-induced epithelial-mesenchymal transition (EMT). In
the present in situ study we validate the role (s) of Nox4 in TGFβ-induced lens EMT leading
to anterior subcapsular cataract (ASC) formation. Mice overexpressing TGFβ in the lens, that
develop ASC, were crossed to Nox4-deficient mice. When comparing mice overexpressing …
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