Optic disc drusen associated anterior ischemic optic neuropathy: prevalence of comorbidities and vascular risk factors

LL Rueløkke, L Malmqvist, M Wegener… - Journal of Neuro …, 2020 - journals.lww.com
LL Rueløkke, L Malmqvist, M Wegener, S Hamann
Journal of Neuro-Ophthalmology, 2020journals.lww.com
Background: Nonarteritic anterior ischemic optic neuropathy (NA-AION) associated with
optic disc drusen (ODD) is termed ODD-AION, where NA-AION with no evidence of ODD is
simply termed NA-AION. Patients with ODD-AION have been found to be younger than those
with NA-AION but with similar vascular risk factors. This study compares the known risk
factors for NA-AION between a group with ODD-AION and a similarly aged group with NA-
AION. Methods: A case–control study of 13 patients with ODD-AION and 14 patients with NA …
Abstract
Background:
Nonarteritic anterior ischemic optic neuropathy (NA-AION) associated with optic disc drusen (ODD) is termed ODD-AION, where NA-AION with no evidence of ODD is simply termed NA-AION. Patients with ODD-AION have been found to be younger than those with NA-AION but with similar vascular risk factors. This study compares the known risk factors for NA-AION between a group with ODD-AION and a similarly aged group with NA-AION.
Methods:
A case–control study of 13 patients with ODD-AION and 14 patients with NA-AION diagnosed in the period 2008–2017. All patients underwent an interview designed to evaluate history of vascular risk factors and comorbidities and re-examination including enhanced depth imaging optical coherence tomography to confirm the presence or absence of ODD.
Results:
No significant differences were found in demographic or clinical characteristics between the ODD-AION and the NA-AION group. Significantly more ODD-AION patients than NA-AION patients had no vascular risk factors (smoking, arterial hypertension, diabetes mellitus, and dyslipidemia) present (P= 0.047). Significantly fewer patients in the ODD-AION group were diagnosed with arterial hypertension or dyslipidemia than in the NA-AION group.
Conclusions:
In this cross-sectional study, the ODD-AION patients more often had no vascular risk factors as compared to NA-AION patients, which supports the hypothesis that ODD are an independent risk factor for AION.
Lippincott Williams & Wilkins
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