Osteopontin in rat renal fibroblasts: functional properties and transcriptional regulation by aldosterone

J Irita, T Okura, M Kurata, K Miyoshi, T Fukuoka… - …, 2008 - Am Heart Assoc
Osteopontin (OPN), a proinflammatory cytokine, plays an important role in renal fibrosis. We
reported that plasma OPN levels were higher in patients with primary aldosteronism than
with essential hypertension. However, the regulatory mechanism of OPN by aldosterone
remains unclear. Here, we report the transcriptional regulation of OPN expression by
aldosterone and the functional effects of aldosterone-mediated OPN transcription in renal
fibroblasts. Aldosterone induced OPN expression in a dose-dependent manner with …

[引用][C] Osteopontin in rat renal fibroblasts: functional properties and transcriptional regulation by aldosterone

入田純 - 2008 - ci.nii.ac.jp
CiNii 博士論文 - Osteopontin in rat renal fibroblasts : functional properties and
transcriptional regulation by aldosteroneOsteopontin in rat renal fibroblasts : functional
properties and transcriptional regulation by aldosterone 腎線維芽細胞におけるアルドステロン
によるオステオポンチン誘導機序とその機能の解明 … Osteopontin in rat renal fibroblasts :
functional properties and transcriptional regulation by aldosterone
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