Outcome measures for autoimmune blistering diseases

CY Zhao, DF Murrell - The Journal of Dermatology, 2015 - Wiley Online Library
CY Zhao, DF Murrell
The Journal of Dermatology, 2015Wiley Online Library
Outcome measures are crucial in assessing an autoimmune blistering disease's (AIBD)
severity as well as its impact on the patient's quality of life (QOL). The standardization of
AIBD outcome measures is pivotal to accurately monitor the patient and to pool results from
randomized controlled trials for meta‐analysis, and thereby provide knowledge of the
optimal AIBD therapies. In the past decade, several AIBD severity outcome measures have
been developed and validated. For pemphigus severity, the Pemphigus Disease Area Index …
Abstract
Outcome measures are crucial in assessing an autoimmune blistering disease's (AIBD) severity as well as its impact on the patient's quality of life (QOL). The standardization of AIBD outcome measures is pivotal to accurately monitor the patient and to pool results from randomized controlled trials for meta‐analysis, and thereby provide knowledge of the optimal AIBD therapies. In the past decade, several AIBD severity outcome measures have been developed and validated. For pemphigus severity, the Pemphigus Disease Area Index (PDAI) developed by the International Pemphigus Definitions Group was shown to be the most superior, followed by the Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) by the German group. For bullous pemphigoid severity, the Bullous Pemphigoid Disease Area Index (BPDAI) was shown to be an accurate and valid measure. To quantify the burden of AIBD and its treatments on QOL, the Autoimmune Bullous Disease Quality of Life (ABQOL) and the Treatment of Autoimmune Bullous Disease Quality of Life (TABQOL) were also developed, validated, and are now being validated in multiple languages and cultures.
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