Overexpression of polycomb protein BMI-1 in human specimens of breast, ovarian, endometrial and cervical cancer
A Honig, C Weidler, S Häusler… - Anticancer …, 2010 - ar.iiarjournals.org
A Honig, C Weidler, S Häusler, M Krockenberger, S Buchholz, F Köster, SE Segerer, J Dietl…
Anticancer Research, 2010•ar.iiarjournals.orgIntroduction: The polycomb group (PcG) proteins form chromatin-modifying complexes that
are commonly deregulated in cancer. The PcG protein BMI-I is overexpressed by various
tumours and thus may contribute to malignant transformation. The current study investigated
the expression of BMI-I in human specimens of breast, ovarian, endometrial and cervical
cancer. Materials and Methods: Expression of BMI-I was evaluated in human ovarian cancer
samples by Western blot analysis and immunohistochemistry (IHC) and compared to healthy …
are commonly deregulated in cancer. The PcG protein BMI-I is overexpressed by various
tumours and thus may contribute to malignant transformation. The current study investigated
the expression of BMI-I in human specimens of breast, ovarian, endometrial and cervical
cancer. Materials and Methods: Expression of BMI-I was evaluated in human ovarian cancer
samples by Western blot analysis and immunohistochemistry (IHC) and compared to healthy …
Introduction
The polycomb group (PcG) proteins form chromatin-modifying complexes that are commonly deregulated in cancer. The PcG protein BMI-I is overexpressed by various tumours and thus may contribute to malignant transformation. The current study investigated the expression of BMI-I in human specimens of breast, ovarian, endometrial and cervical cancer. Materials and Methods
Expression of BMI-I was evaluated in human ovarian cancer samples by Western blot analysis and immunohistochemistry (IHC) and compared to healthy ovarian tissue. BMI-I expression in human specimens of breast, endometrial and cervical cancer was evaluated by IHC and then compared with the respective benign tissues. Results
BMI-I was significantly (p<0.05) overexpressed in human breast, ovarian, endometrial and cervical cancer specimens as compared to benign controls. BMI-I expression was also more pronounced in the ovarian cancer samples as demonstrated by Western blot analysis. In human breast cancer samples, BMI-I expression was most pronounced in the invasion front of the tumour. Conclusion
The current study showed for the first time that the BMI-I protein is significantly overexpressed in ovarian, endometrial and cervical cancer and may thus be a potential target for novel antitumor therapies.ar.iiarjournals.org
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