[PDF][PDF] Oxidative stress and chronological aging in glycogen-phosphorylase-deleted yeast
C Favre, PS Aguilar, MC Carrillo - Free Radical Biology and …, 2008 - academia.edu
C Favre, PS Aguilar, MC Carrillo
Free Radical Biology and Medicine, 2008•academia.edu… Among the deletions that produced cells that accumulated greater amounts of glycogen,
gph1Δ (glycogen phosphorylase knockout) showed rapid chronological aging and
demonstrated low stress tolerance. We compared the levels of reactive oxygen species and
activation of apoptosis in these aging yeasts. Results indicate that a mutation impeding
glycogen breakdown shows decreased chronological longevity and a diminished
expression of Cu/Zn- and Mn-SOD. …
gph1Δ (glycogen phosphorylase knockout) showed rapid chronological aging and
demonstrated low stress tolerance. We compared the levels of reactive oxygen species and
activation of apoptosis in these aging yeasts. Results indicate that a mutation impeding
glycogen breakdown shows decreased chronological longevity and a diminished
expression of Cu/Zn- and Mn-SOD. …
Cristián Favre a,⁎, Pablo S. Aguilar b, María C. Carrillo a a Institute of Experimental Physiology, CONICET, School of Biochemical Sciences, University of Rosario, Rosario, Argentina b Institut Pasteur Montevideo, Montevideo, Uruguay abstract articleinfo
academia.edu
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