PIN1 facilitates ubiquitin-mediated degradation of serine/threonine kinase 3 and promotes melanoma development via TAZ activation
G Kim, PY Bhattarai, SC Lim, JY Kim, HS Choi - Cancer Letters, 2021 - Elsevier
The Hippo signaling pathway controls cellular processes including growth, homeostasis,
and apoptosis. The kinase STK3 acts upstream in this pathway to activate LATS1/2 kinase,
which phosphorylates and inactivates the transcriptional coactivators YAP/TAZ. The
dysregulation of Hippo signaling leads to human diseases including cancer; however, the
molecular mechanisms underlying its dysregulation in melanoma are unknown. We aimed
to determine the role of the PIN1 in Hippo signaling dysregulation and melanoma …
and apoptosis. The kinase STK3 acts upstream in this pathway to activate LATS1/2 kinase,
which phosphorylates and inactivates the transcriptional coactivators YAP/TAZ. The
dysregulation of Hippo signaling leads to human diseases including cancer; however, the
molecular mechanisms underlying its dysregulation in melanoma are unknown. We aimed
to determine the role of the PIN1 in Hippo signaling dysregulation and melanoma …
