Parkinson's disease I: glucocerebrosidase mutations, family history of melanoma and questionable effects of rasagiline

M Strupp - Journal of neurology, 2009 - search.proquest.com
Journal of neurology, 2009search.proquest.com
Looking through the major journals, it is amazing to see how many papers are published
every month on Parkinson's disease. They cover genetics, associations with other disorders,
neuropsychological deficits, long-term follow-up studies and new treatment options.
Therefore, this month and next month the Journal Club will focus on recent papers on
Parkinson's disease with the aim of highlighting current developments. Going through the
literature, it is also remarkable to note that Parkinson's disease is spelt in different ways: eg …
Looking through the major journals, it is amazing to see how many papers are published every month on Parkinson’s disease. They cover genetics, associations with other disorders, neuropsychological deficits, long-term follow-up studies and new treatment options. Therefore, this month and next month the Journal Club will focus on recent papers on Parkinson’s disease with the aim of highlighting current developments.
Going through the literature, it is also remarkable to note that Parkinson’s disease is spelt in different ways: eg in the New England Journal of Medicine it is ‘‘Parkinson’s disease’’and in Neurology it is ‘‘Parkinson disease’’. Perhaps the editors of the different journals should try to find a uniform spelling. As an advocate of historical accuracy, the author of the Journal Club would argue for ‘‘Parkinson’s disease’’. This month’s Journal Club will focus on three papers. In the first article, published in the New England Journal of Medicine, a strong association between glucocerebrosidase mutations (a deficiency of which causes Gaucher’s disease) and Parkinson’s disease was demonstrated. The second article shows a clear association of Parkinson’s disease with a family history of melanoma. The final article, also published in the New England Journal of Medicine, gives some questionable evidence that the inhibitor of monoamineoxidase type B, rasagiline, might have a diseasemodifying effect, but only in a dose of 1 mg per day without showing an effect in a dose of 2 mg per day.
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