Patient‐reported outcomes from a single‐centre prospective post‐marketing study on Collagenase Clostridium Histolyticum injections for Peyronie's disease
CFS Jensen, FM Jacobsen, S Quallich, M Fode… - Andrologia, 2020 - Wiley Online Library
Andrologia, 2020•Wiley Online Library
The aim of this study was to evaluate patient‐reported outcomes of Collagenase Clostridium
Histolyticum (CCHi) for Peyronie's Disease. Patients treated with 2–4 cycles of CCHi
between 01/2016 and 08/2018 were asked to fill out the “bother domain” of the Peyronie's
Disease Questionnaire (PDQ) at scheduled appointments for injections. CCHi cycles
involved two injections (0.58 mg) separated by 48–72 hr. During the study, 34 patients were
treated, seven patients were excluded due to incomplete baseline values. Mean (standard …
Histolyticum (CCHi) for Peyronie's Disease. Patients treated with 2–4 cycles of CCHi
between 01/2016 and 08/2018 were asked to fill out the “bother domain” of the Peyronie's
Disease Questionnaire (PDQ) at scheduled appointments for injections. CCHi cycles
involved two injections (0.58 mg) separated by 48–72 hr. During the study, 34 patients were
treated, seven patients were excluded due to incomplete baseline values. Mean (standard …
Abstract
The aim of this study was to evaluate patient‐reported outcomes of Collagenase Clostridium Histolyticum (CCHi) for Peyronie's Disease. Patients treated with 2–4 cycles of CCHi between 01/2016 and 08/2018 were asked to fill out the “bother domain” of the Peyronie's Disease Questionnaire (PDQ) at scheduled appointments for injections. CCHi cycles involved two injections (0.58 mg) separated by 48–72 hr. During the study, 34 patients were treated, seven patients were excluded due to incomplete baseline values. Mean (standard deviation) PDQ bother domain baseline score was 11.1 (2.6). ANOVA demonstrated statistically significant effects of injections (p < .001) with a decrease in PDQ bother domain scores 6 weeks after the 1st cycle (9.9 [3.3], p = .013), 6 weeks after the 2nd cycle (8.2 [4.0], p = .009) and 6 weeks after the 3rd cycle (6.5 [3.6], p < .001). After 2–4 cycles of CCHi treatment, patients reported changes in penile curvature as “Worse” (0), “No Change” (2), “Little decrease” (10), Decrease (10) and “Significant decrease” (4). After completion of CCHi treatment, 82% of patients still reported that vaginal intercourse was difficult or impossible. Patients with Peyronie's Disease undergoing CCHi treatment reported statistically significant decreases in PDQ bother domain scores. However, most patients still report difficulty with intercourse after treatment.
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