[HTML][HTML] Peptidomimetic inhibitors for activated protein C: implications for hemophilia management
S Butenas, T Orfeo, M Kalafatis, KG Mann - Journal of Thrombosis and …, 2006 - Elsevier
Background: Several clinical studies and experiments with transgenic mice have suggested
that the severity of the bleeding phenotype in hemophilic patients is substantially reduced in
association with impaired inactivation of factor (F) Va by activated protein C (APC) in the
presence of the FV Leiden mutation. Experiments using a synthetic coagulation proteome
model showed that the presence of FV Leiden significantly increased thrombin generation in
the absence of FVIII or FIX. Objective: To test the effect of APC inhibition on thrombin …
that the severity of the bleeding phenotype in hemophilic patients is substantially reduced in
association with impaired inactivation of factor (F) Va by activated protein C (APC) in the
presence of the FV Leiden mutation. Experiments using a synthetic coagulation proteome
model showed that the presence of FV Leiden significantly increased thrombin generation in
the absence of FVIII or FIX. Objective: To test the effect of APC inhibition on thrombin …
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