The pharmacokinetics of amlodipine was studied in 27 subjects with renal function ranging
from normal to dialysis-dependent. Amlodipine (as a single 5-mg capsule) was administered
once daily for 14 days and its plasma concentrations were measured by gas
chromatography during and after treatment. Renal impairment had little or no effect on the
pharmacokinetics of amlodipine. The elimination half-life was of the order of 50 h, similar to
previously observed values, and did not vary with differences in renal function. Steady-state …

Amlodipine was administered as 14 single 5-mg oral daily doses to 27 male subjects with
renal function ranging from normal to haemodialysis-dependent. Blood specimens were
obtained for measurement of plasma amlodipine concentrations for 24 h following the first
dose, for 168 h following the final dose and during daily administration of amlodipine.
Amlodipine was well tolerated. Renal impairment had little effect on the pharmacokinetics of
amlodipine. The elimination half-life was of the order of 50 h, similar to previously reported …