Pharmacokinetics of levofloxacin during continuous veno-venous hemofiltration

E Hansen, M Bucher, W Jakob, P Lemberger… - Intensive care …, 2001 - Springer
Objective: To study the effect of continuous veno-venous hemofiltration (CVVHF) on the
pharmacokinetics of levofloxacin in critically ill patients with acute renal failure. Design:
Open-label study. Setting: Anesthesiology ICU, University Hospital of Regensburg. Patients:
Six critically ill patients treated with CVVHF because of acute renal failure needing
antimicrobial therapy. Interventions: Levofloxacin iv 250 mg qd with a starting dose of 500
mg. CVVHF with the following characteristics: hemofilter AN69 hollow fibers of 0.90 m 2 …

Pharmacokinetics of levofloxacin during continuous venovenous hemodiafiltration and continuous venovenous hemofiltration in critically ill patients

SG Guenter, H Iven, C Boos… - … : The Journal of …, 2002 - Wiley Online Library
Study Objective. To assess the pharmacokinetics of levofloxacin during continuous
venovenous hemodiafiltration (CVVHDF) and continuous venovenous hemofiltration
(CVVH). Design. Nonrandomized pharmacokinetic evaluation. Setting. University surgical
intensive care unit. Patients. Six critically ill patients. Intervention. Five patients received
levofloxacin 500 mg/day and one patient received levofloxacin 125 mg/day. All patients
received continuous renal replacement therapy: CVVHDF on day 1 and CVVH on day 2 …
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