Systemic administration does not allow a clear differentiation between the anticonvulsant
properties of GABAA (γ-aminobutyric acid) modulators. For this reason, various GABAA
modulators have previously been micro-infused into seizure controlling substrates (area
tempestas, substantia nigra) in the rat brain as a screening method for potential systemic
administration. The purpose of the present study was to examine the anticonvulsant impact
of the GABAergic modulators muscimol, ethanol, and propofol (screened by micro-infusions) …