Photoreactivity of nifedipine in vitro and in vivo
H de Vries, GMJB van Henegouwen - Journal of Photochemistry and …, 1998 - Elsevier
Side effects of nitroaromatics used as drugs are often assumed to be caused by incomplete
enzymatic reduction of the nitro group. However, photoactivation, although usually not
considered as a cause of the toxic effects of nitroaromatics, can play a considerable role.
Nifedipine, a nitroaromatic as well, is an important drug used in the treatment of myocardial
ischaemia and hypertension. It is extremely sensitive to ultraviolet and visible light up to 450
nm and forms a nitroso derivative in vitro. In the present study it is shown that the nitroso …
enzymatic reduction of the nitro group. However, photoactivation, although usually not
considered as a cause of the toxic effects of nitroaromatics, can play a considerable role.
Nifedipine, a nitroaromatic as well, is an important drug used in the treatment of myocardial
ischaemia and hypertension. It is extremely sensitive to ultraviolet and visible light up to 450
nm and forms a nitroso derivative in vitro. In the present study it is shown that the nitroso …
