Phototoxicity of methoxsalen in various vehicles
R Suhonen - Contact Dermatitis, 1976 - Wiley Online Library
R Suhonen
Contact Dermatitis, 1976•Wiley Online LibraryMethoxsalen (8‐methoxypsoralen) was used as the phototoxic substance in the study of the
properties of various vehicles in photoepicutaneous testing. Macrogols as such were
relatively poor bases, and positive reactions were seen only occasionally at a concentration
of 0.05% methoxsalen. Increasing amounts of water in macrogols brought forth more
numerous and stronger reactions. The phototoxicity also increased when ethanol was
added. The reactions were, however, weaker thantothose with aqueous bases. Wool fat and …
properties of various vehicles in photoepicutaneous testing. Macrogols as such were
relatively poor bases, and positive reactions were seen only occasionally at a concentration
of 0.05% methoxsalen. Increasing amounts of water in macrogols brought forth more
numerous and stronger reactions. The phototoxicity also increased when ethanol was
added. The reactions were, however, weaker thantothose with aqueous bases. Wool fat and …
Methoxsalen (8‐methoxypsoralen) was used as the phototoxic substance in the study of the properties of various vehicles in photoepicutaneous testing. Macrogols as such were relatively poor bases, and positive reactions were seen only occasionally at a concentration of 0.05 % methoxsalen.
Increasing amounts of water in macrogols brought forth more numerous and stronger reactions. The phototoxicity also increased when ethanol was added. The reactions were, however, weaker thantothose with aqueous bases.
Wool fat and glycerol as vehicles usually reacted in the same way as polyethylene glycols when water was added. An explanation of the mechanism of the changes in the properties of vehicles due to the addition of water/ethanol requires further investigation.
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