Physiological interactions between enkephalin and excitatory amino acids in the cerebellar cortex of the opossum Didelphis marsupialis virginiana

GA Bishop - Neuroscience, 1991 - Elsevier
The opiate peptide enkephalin has been immunohistochemically localized within specific
populations of climbing fibers and mossy fibers in the opossum's cerebellum. The intention
of the present study was to determine the physiological effects of this peptide on Purkinje
cell activity as well as to examine interactions between this peptide and the excitatory amino
acids glutamate and aspartate. lontophoretic application of enkephalin onto Purkinje cells in
the posterior lobe vermis and adjacent hemisphere suppressed activity in nine of 16 (56%) …
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