Pigment epithelium-derived factor improves TNFα-induced hepatic steatosis in grass carp (Ctenopharyngodon idella)
Z Yang, J Sun, XC Shi, Y Li, ZY Du, LQ Chen - Developmental & …, 2017 - Elsevier
Pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNFα), may contribute to
hepatic steatosis in the situation of excess lipid accumulation in farmed fish. Pigment
epithelium-derived factor (PEDF) is an endogenous anti-inflammatory factor and promotes
lipolysis. Accordingly, we isolated PEDF from grass carp and investigated its role in TNFα-
induced hepatic steatosis. Sequence analysis showed that PEDF gene, which possesses 8
exons and 7 introns, encodes a protein with 409 amino acids. PEDF was a critical …
hepatic steatosis in the situation of excess lipid accumulation in farmed fish. Pigment
epithelium-derived factor (PEDF) is an endogenous anti-inflammatory factor and promotes
lipolysis. Accordingly, we isolated PEDF from grass carp and investigated its role in TNFα-
induced hepatic steatosis. Sequence analysis showed that PEDF gene, which possesses 8
exons and 7 introns, encodes a protein with 409 amino acids. PEDF was a critical …
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