[HTML][HTML] Pioglitazone attenuates experimental colitis-associated hyperalgesia through improving the intestinal barrier dysfunction
Y Huang, C Wang, X Tian, Y Mao, B Hou, Y Sun, X Gu… - Inflammation, 2020 - Springer
Impaired intestinal mucosal integrity during colitis involves the peroxisome proliferator-
activated receptor-γ (PPARγ), an important anti-inflammatory factor in intestinal mucosa
homoeostasis, which is a potential target in colitis. Recurrent chronic pain is a vital
pathogenetic feature of colitis. Nevertheless, potential functions of PPARγ in the colitis-
associated hyperalgesia remain unclear. This study aimed to investigate biological roles of
pioglitazone in relieving colitis-associated pain hypersensitivity by a PPARγ tight junction …
activated receptor-γ (PPARγ), an important anti-inflammatory factor in intestinal mucosa
homoeostasis, which is a potential target in colitis. Recurrent chronic pain is a vital
pathogenetic feature of colitis. Nevertheless, potential functions of PPARγ in the colitis-
associated hyperalgesia remain unclear. This study aimed to investigate biological roles of
pioglitazone in relieving colitis-associated pain hypersensitivity by a PPARγ tight junction …
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