Plasmodium falciparum antigenic variation. Mapping mosaic var gene sequences onto a network of shared, highly polymorphic sequence blocks
PC Bull, CO Buckee, S Kyes, MM Kortok… - Molecular …, 2008 - Wiley Online Library
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a potentially important
family of immune targets, encoded by an extremely diverse gene family called var.
Understanding of the genetic organization of var genes is hampered by sequence
mosaicism that results from a long history of non‐homologous recombination. Here we have
used software designed to analyse social networks to visualize the relationships between
large collections of short var sequences tags sampled from clinical parasite isolates. In this …
family of immune targets, encoded by an extremely diverse gene family called var.
Understanding of the genetic organization of var genes is hampered by sequence
mosaicism that results from a long history of non‐homologous recombination. Here we have
used software designed to analyse social networks to visualize the relationships between
large collections of short var sequences tags sampled from clinical parasite isolates. In this …
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