Plectin is a widely expressed protein that is very large in size and that has all the attributes of
a multifunctional crosslinking and organizing element of the cytoskeleton. It displays a
multidomain structure, versatile binding activities, and subcellular localizations that enable it
to strengthen cells against mechanical stress forces. Moreover, hereditary gene defects in
plectin cause epidermolysis bullosa simplex (EBS)-MD, a severe skin blistering disease with
muscular dystrophy. Here we report the analysis of the exon–intron organization of the rat …