Multidrug resistance (MDR) remains one of the biggest obstacles for effective cancer
therapy. Currently there are only few methods that are available clinically that are used to
bypass MDR with very limited success. In this review we describe how MDR can be
overcome by a simple yet effective approach of using amphiphilic block copolymers. Triblock
copolymers of poly (ethylene oxide)(PEO) and poly (propylene oxide)(PPO), arranged in a
triblock structure PEO-PPO-PEO, Pluronics or “poloxamers”, raised a considerable interest …