Positivity for HLA DR1 is associated with basal cell carcinoma in renal transplant patients in southern Brazil
AVE de Carvalho, RR Bonamigo… - International Journal …, 2012 - Wiley Online Library
AVE de Carvalho, RR Bonamigo, CM da Silva, AC De Zorzi Pinto
International Journal of Dermatology, 2012•Wiley Online LibraryBackground Renal transplant patients have a higher incidence of non‐melanoma skin
cancer (NMSC). Previous studies hypothesized that human leukocyte antigen (HLA),
especially types DR1, DR4, and DR7, may influence the incidence of these tumors. This
study investigates the association between NMSC and the presence of HLA DR1, DR4, and
DR7 in renal transplant patients in southern Brazil. Methods In a historical cohort study,
1032 patients who underwent renal transplantation during the period from January 1993 to …
cancer (NMSC). Previous studies hypothesized that human leukocyte antigen (HLA),
especially types DR1, DR4, and DR7, may influence the incidence of these tumors. This
study investigates the association between NMSC and the presence of HLA DR1, DR4, and
DR7 in renal transplant patients in southern Brazil. Methods In a historical cohort study,
1032 patients who underwent renal transplantation during the period from January 1993 to …
Abstract
Background Renal transplant patients have a higher incidence of non‐melanoma skin cancer (NMSC). Previous studies hypothesized that human leukocyte antigen (HLA), especially types DR1, DR4, and DR7, may influence the incidence of these tumors. This study investigates the association between NMSC and the presence of HLA DR1, DR4, and DR7 in renal transplant patients in southern Brazil.
Methods In a historical cohort study, 1032 patients who underwent renal transplantation during the period from January 1993 to December 2006 were examined to identify occurrences of NMSC and HLA status prior to transplant.
Results Of the 1032 patients examined, 59 (5.71%) developed NMSC (squamous cell carcinoma [SCC]: 2.42%; basal cell carcinoma [BCC]: 1.74%; both: 1.55%). The presence of HLA DR1 was associated with a higher probability of developing any NMSC and particularly with developing BCC (P < 0.05). There was no statistically significant association between the presence of HLA DR4 or DR7 and the occurrence of NMSC in this sample.
Conclusions HLA DR1 appears to be associated with the development of BCC, as well as with the higher number of NMSC lesions in renal transplant patients. This study supports the trend to associate the DR1 allele with BCC and not with SCC.
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