Obesity is a well-established risk factor for colorectal cancer (CRC), but the association with
the tumor microenvironment has been sparsely described. Herein, we examined the
relationship between pre-diagnostic anthropometry and CRC risk according to tumor
immune cell composition, with particular reference to potential sex differences. The density
of different immune cell subsets was assessed by immunohistochemistry in tissue
microarrays with tumors from 584 incident CRC cases in a prospective, population-based …

Background: Obesity is a well-established risk factor for colorectal cancer (CRC), but
whether this risk differs according to CRC subtype defined by the tumor immune
microenvironment has been sparsely described. Herein, we examined the relationship
between pre-diagnostic anthropometry and CRC risk according to tumor-infiltrating immune
cell composition, with particular reference to potential sex differences. Methods: The density
of immune cells expressing PD1, PD-L1 (PD-L1/IC), CD3, CD8, FoxP3, CD20, CD68 …