In the past decade, adenovirus vectors have generated tremendous interest, especially in
gene therapy applications. In the so-called 'first generation'adenovirus vectors, the
transgenes are inserted in place of the E1 region, or less often the E3 region. Although
second-generation and helper-dependent adenovirus vectors will probably prevail in the
future in applications that require long-term gene expression, first generation adenovirus
vectors will remain very useful in other settings, such as cancer and vaccination, or simply to …