Programmed death-1 (PD-1) is a marker of germinal center-associated T cells and angioimmunoblastic T-cell lymphoma
DM Dorfman, JA Brown, A Shahsafaei… - The American journal …, 2006 - journals.lww.com
Abstract Programmed death-1 (PD-1), a member of the CD28 costimulatory receptor family,
is expressed by germinal center-associated T cells in reactive lymphoid tissue. In a study of
a wide range of lymphoproliferative disorders, neoplastic T cells in 23 cases of
angioimmunoblastic lymphoma were immunoreactive for PD-1, but other subtypes of T cell
and B cell non-Hodgkin lymphoma, as well as classic Hodgkin lymphoma, did not express
PD-1. The pattern of PD-1 immunostaining of neoplastic cells in angioimmunoblastic …
is expressed by germinal center-associated T cells in reactive lymphoid tissue. In a study of
a wide range of lymphoproliferative disorders, neoplastic T cells in 23 cases of
angioimmunoblastic lymphoma were immunoreactive for PD-1, but other subtypes of T cell
and B cell non-Hodgkin lymphoma, as well as classic Hodgkin lymphoma, did not express
PD-1. The pattern of PD-1 immunostaining of neoplastic cells in angioimmunoblastic …
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