Pyrinodemins E and F, new 3-alkylpyridine alkaloids from sponge Amphimedon sp.
K Kura, T Kubota, J Fromont, J Kobayashi - Bioorganic & medicinal …, 2011 - Elsevier
K Kura, T Kubota, J Fromont, J Kobayashi
Bioorganic & medicinal chemistry letters, 2011•ElsevierTwo new 3-alkylpyridine alkaloids, pyrinodemins E (1) and F (2), were isolated from an
Okinawan marine sponge Amphimedon sp. and the structures of 1 and 2 were elucidated on
the basis of spectroscopic data. Pyrinodemins E (1) and F (2) were novel 3-alkylpyridine
alkaloids possessing a 4-(methoxyamino) piperidinone moiety and an indol-3-glyoxylamide
moiety, respectively. Pyrinodemin E (1) showed cytotoxicity against P388 and L1210 murine
leukemia cells.
Okinawan marine sponge Amphimedon sp. and the structures of 1 and 2 were elucidated on
the basis of spectroscopic data. Pyrinodemins E (1) and F (2) were novel 3-alkylpyridine
alkaloids possessing a 4-(methoxyamino) piperidinone moiety and an indol-3-glyoxylamide
moiety, respectively. Pyrinodemin E (1) showed cytotoxicity against P388 and L1210 murine
leukemia cells.
Two new 3-alkylpyridine alkaloids, pyrinodemins E (1) and F (2), were isolated from an Okinawan marine sponge Amphimedon sp. and the structures of 1 and 2 were elucidated on the basis of spectroscopic data. Pyrinodemins E (1) and F (2) were novel 3-alkylpyridine alkaloids possessing a 4-(methoxyamino)piperidinone moiety and an indol-3-glyoxylamide moiety, respectively. Pyrinodemin E (1) showed cytotoxicity against P388 and L1210 murine leukemia cells.
Elsevier
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