Quantifying in vivo murine antigen-specific T cell responses without requirement for prior knowledge of antigen identity
Extracorporeal Photochemotherapy (ECP) is a widely applied anti-cancer immunotherapy
for patients with cutaneous T cell lymphoma (CTCL). By using apoptotic malignant cells as a
source of patient-specific tumor antigen, it enables clinically relevant and curative anti-CTCL
immunity, with potential efficacy in other tumors. Currentmethods to track patient-specific
responses are tedious, and new methods are needed to assess putative global immunity.
We developed a clinically practical method to assess antigen-specific T cell activation that …
for patients with cutaneous T cell lymphoma (CTCL). By using apoptotic malignant cells as a
source of patient-specific tumor antigen, it enables clinically relevant and curative anti-CTCL
immunity, with potential efficacy in other tumors. Currentmethods to track patient-specific
responses are tedious, and new methods are needed to assess putative global immunity.
We developed a clinically practical method to assess antigen-specific T cell activation that …
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