Rab33B controls hepatitis B virus assembly by regulating core membrane association and nucleocapsid processing
C Bartusch, T Döring, R Prange - Viruses, 2017 - mdpi.com
Many viruses take advantage of cellular trafficking machineries to assemble and release
new infectious particles. Using RNA interference (RNAi), we demonstrate that the
Golgi/autophagosome-associated Rab33B is required for hepatitis B virus (HBV)
propagation in hepatoma cell lines. While Rab33B is dispensable for the secretion of HBV
subviral envelope particles, its knockdown reduced the virus yield to 20% and inhibited
nucleocapsid (NC) formation and/or NC trafficking. The overexpression of a GDP-restricted …
new infectious particles. Using RNA interference (RNAi), we demonstrate that the
Golgi/autophagosome-associated Rab33B is required for hepatitis B virus (HBV)
propagation in hepatoma cell lines. While Rab33B is dispensable for the secretion of HBV
subviral envelope particles, its knockdown reduced the virus yield to 20% and inhibited
nucleocapsid (NC) formation and/or NC trafficking. The overexpression of a GDP-restricted …
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