Reduction of stenosis due to intimal hyperplasia after stent supported angioplasty of peripheral arteries by local administration of paclitaxel in swine
T Albrecht, U Speck, C Baier, KJ Wolf… - Investigative …, 2007 - journals.lww.com
T Albrecht, U Speck, C Baier, KJ Wolf, M Böhm, B Scheller
Investigative radiology, 2007•journals.lww.comPurpose: To assess if local intra-arterial administration of paclitaxel using drug-coated
balloons or an admixture of paclitaxel to contrast medium inhibits stenosis after percutanous
transluminal angioplasty (PTA) of peripheral arteries in a porcine overstretch model.
Methods: Neointimal proliferation and stenosis were induced by overstretch and stenting of
40 peripheral arteries in 20 pigs. Paclitaxel was administered locally during PTA using
coated balloons (n= 20) or dissolved in contrast medium (n= 10). Conventional balloons and …
balloons or an admixture of paclitaxel to contrast medium inhibits stenosis after percutanous
transluminal angioplasty (PTA) of peripheral arteries in a porcine overstretch model.
Methods: Neointimal proliferation and stenosis were induced by overstretch and stenting of
40 peripheral arteries in 20 pigs. Paclitaxel was administered locally during PTA using
coated balloons (n= 20) or dissolved in contrast medium (n= 10). Conventional balloons and …
Abstract
Purpose:
To assess if local intra-arterial administration of paclitaxel using drug-coated balloons or an admixture of paclitaxel to contrast medium inhibits stenosis after percutanous transluminal angioplasty (PTA) of peripheral arteries in a porcine overstretch model.
Methods:
Neointimal proliferation and stenosis were induced by overstretch and stenting of 40 peripheral arteries in 20 pigs. Paclitaxel was administered locally during PTA using coated balloons (n= 20) or dissolved in contrast medium (n= 10). Conventional balloons and contrast medium were used in a control group (n= 10). Reangiography with quantitative analysis was performed after 5 weeks.
Results:
On reangiography diameter stenosis and late lumen loss were significantly reduced by both methods of local drug delivery compared with control group; minimal luminal diameter was significantly larger in the treatment groups.
Conclusions:
Local short-term administration of paclitaxel during PTA of peripheral arteries using balloons or contrast medium as drug carriers reduced stenosis due to intimal hyperplasia.
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