The invited commentary of Mayer and Ziemann about our original article on venous
angioplasty in chronic cerebrospinal venous insufficiency in multiple sclerosis patients
(CCSVI-MS) 1, 2 raises several important questions in relation to the methodology of our
study. The authors criticise our preliminary findings and doubt the blinded assessment of the
reported magnetic resonance imaging (MRI) measures that represented the primary
outcome measures in this study, as generally accepted in pilot safety and preliminary …