[HTML][HTML] Regulation of immune response by S‑1‑propenylcysteine through autophagy‑mediated protein degradation
JI Suzuki, S Miki, M Ushijima… - Experimental and …, 2020 - spandidos-publications.com
Autophagy is a key event in cellular recycling processes due to its involvement in the
intracellular degradation of proteins. It has been demonstrated that S‑1‑propenylcysteine
(S1PC), a characteristic sulfur compound in aged garlic extract, induces the activation of
autophagy. S1PC degrades the adaptor protein myeloid differentiation response protein 88
(MyD88) of downstream of Toll‑like receptor (TLR) by activating autophagy in vitro and in
vivo. The degradation of MyD88 inhibits the TLR signaling pathway, including the …
intracellular degradation of proteins. It has been demonstrated that S‑1‑propenylcysteine
(S1PC), a characteristic sulfur compound in aged garlic extract, induces the activation of
autophagy. S1PC degrades the adaptor protein myeloid differentiation response protein 88
(MyD88) of downstream of Toll‑like receptor (TLR) by activating autophagy in vitro and in
vivo. The degradation of MyD88 inhibits the TLR signaling pathway, including the …
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