Relationship between renal plasma flow response to angiotensin II and blood pressure in a population-based sample

ST Turner, SLR Kardia - Journal of hypertension, 1997 - journals.lww.com
ST Turner, SLR Kardia
Journal of hypertension, 1997journals.lww.com
Objective To assess whether interindividual variation in renal plasma flow or in its response
to angiotensin II infusion is associated with interindividual differences in blood pressure in a
population-based sample of 287 non-Hispanic whites (143 women and 144 men), aged 20–
49.9 years. Methods After seven days of eating a high-sodium diet (260 mmol/day), the renal
plasma flow was determined by measuring the clearance of p-aminohippurate before and
after infusion of 3 ng/kg per min angiotensin II. Multiple linear regression methods were used …
Abstract
Objective
To assess whether interindividual variation in renal plasma flow or in its response to angiotensin II infusion is associated with interindividual differences in blood pressure in a population-based sample of 287 non-Hispanic whites (143 women and 144 men), aged 20–49.9 years.
Methods
After seven days of eating a high-sodium diet (260 mmol/day), the renal plasma flow was determined by measuring the clearance of p-aminohippurate before and after infusion of 3 ng/kg per min angiotensin II. Multiple linear regression methods were used to assess whether measures of the renal plasma flow and of its response to angiotensin II infusion were predictive of systolic or diastolic blood pressures measured prior to administration of the high-sodium diet, on day 6 of the high-sodium diet, or during the renal clearance procedure on day 7 prior to angiotensin II infusion.
Results
There was some evidence that measures of the renal plasma flow and of its response to angiotensin II infusion during the high-sodium diet were statistically significant predictors of measures of blood pressure in women; there was less evidence for this for blood pressures in men. Interindividual variation in measures of the renal plasma flow and of its response to angiotensin II infusion explained less than 10% of the interindividual variation in any measure of the blood pressure in both sexes.
Conclusion
These results suggest that interindividual variation in renal plasma flow and in its response to angiotensin II infusion during a high-sodium diet will be of limited utility in elucidating the basis for interindividual differences in blood pressure.
Lippincott Williams & Wilkins
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