Seizures have both local and remote effects on nervous system function. Whereas
propagated seizures are known to disrupt cerebral activity, little work has been done on
remote network effects of seizures that do not propagate. Human focal temporal lobe
seizures demonstrate remote changes including slow waves on electroencephalography
(EEG) and decreased cerebral blood flow (CBF) in the neocortex. Ictal neocortical slow
waves have been interpreted as seizure propagation; however, we hypothesize that they …

Abstract REMOTE EFFECTS OF FOCAL HIPPOCAMPAL SEIZURES ON THE RAT
NEOCORTEX. Peter K. Mansuripur, Dario J. Englot, Asht M. Mishra, Peter Herman,
Fahmeed Hyder, and Hal Blumenfeld. Department of Neurology, Yale University, School of
Medicine, New Haven, CT. The goal of this study is to establish an animal model of frontal
lobe slow-wave activity during complex partial hippocampal seizures, to characterize this
activity in terms of its behavioral, neuronal and metabolic activity, and to compare it to …