Resveratrol enhances insulin secretion by blocking KATP and KV channels of beta cells
WP Chen, TC Chi, LM Chuang, MJ Su - European journal of pharmacology, 2007 - Elsevier
The present study investigated the effect of resveratrol on the electrophysiology and insulin
secretion of pancreatic beta cells, and examined resveratrol-induced alterations in insulin
levels and plasma glucose of normal and streptozotocin-induced diabetic rats. Whole-cell
voltage clamp study in the MIN6 cell, a mouse β cell line, revealed that resveratrol
significantly inhibited ATP-sensitive K+ current at 3 μmol/l, and voltage-gated K+ currents at
30 μmol/l. Ca2+-activated K+ current was activated by resveratrol at 100 μmol/l. In MIN6 …
secretion of pancreatic beta cells, and examined resveratrol-induced alterations in insulin
levels and plasma glucose of normal and streptozotocin-induced diabetic rats. Whole-cell
voltage clamp study in the MIN6 cell, a mouse β cell line, revealed that resveratrol
significantly inhibited ATP-sensitive K+ current at 3 μmol/l, and voltage-gated K+ currents at
30 μmol/l. Ca2+-activated K+ current was activated by resveratrol at 100 μmol/l. In MIN6 …
Resveratrol enhances insulin secretion by blocking KATP and KV channels of beta cells.
CWP Chen WenPin, CTC Chi TzongCherng… - 2007 - cabidigitallibrary.org
The present study investigated the effect of resveratrol on the electrophysiology and insulin
secretion of pancreatic beta cells, and examined resveratrol-induced alterations in insulin
levels and plasma glucose of normal and streptozotocin-induced diabetic rats. Whole-cell
voltage clamp study in the MIN6 cell, a mouse β cell line, revealed that resveratrol
significantly inhibited ATP-sensitive K+ current at 3 µmol/l, and voltage-gated K+ currents at
30 µmol/l. Ca2+-activated K+ current was activated by resveratrol at 100 µmol/l. In MIN6 …
secretion of pancreatic beta cells, and examined resveratrol-induced alterations in insulin
levels and plasma glucose of normal and streptozotocin-induced diabetic rats. Whole-cell
voltage clamp study in the MIN6 cell, a mouse β cell line, revealed that resveratrol
significantly inhibited ATP-sensitive K+ current at 3 µmol/l, and voltage-gated K+ currents at
30 µmol/l. Ca2+-activated K+ current was activated by resveratrol at 100 µmol/l. In MIN6 …
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