[PDF][PDF] Reversal MDR in breast carcinoma cells by transfection of ribozyme designed according the secondary structure of mdr1 mRNA
P Gao, G Zhou, Q Zhang, H Li, K Mu, Y Yuan… - Chinese Journal of …, 2006 - cps.org.tw
P Gao, G Zhou, Q Zhang, H Li, K Mu, Y Yuan, J Zhang, B Wang
Chinese Journal of Physiology, 2006•cps.org.twMultidrug resistance (MDR) is a major obstacle in cancer chemotherapy. The present study
aims to investigate whether the ribozyme could reverse MDR in breast carcinoma cells. In
this study, two GUC sites (GUC106 and GUC135) on the surface of mdr1 mRNA were
selected according to the secondary structure of the 5'-region of mdr1 mRNA. The ribozyme
gene RZ106 and RZ135 complementary to two sides bases of the target GUC were
synthesized and cloned into the plasmid pEGFP-C1 which has EGFP
aims to investigate whether the ribozyme could reverse MDR in breast carcinoma cells. In
this study, two GUC sites (GUC106 and GUC135) on the surface of mdr1 mRNA were
selected according to the secondary structure of the 5'-region of mdr1 mRNA. The ribozyme
gene RZ106 and RZ135 complementary to two sides bases of the target GUC were
synthesized and cloned into the plasmid pEGFP-C1 which has EGFP
Abstract
Multidrug resistance (MDR) is a major obstacle in cancer chemotherapy. The present study aims to investigate whether the ribozyme could reverse MDR in breast carcinoma cells. In this study, two GUC sites (GUC106 and GUC135) on the surface of mdr1 mRNA were selected according to the secondary structure of the 5'-region of mdr1 mRNA. The ribozyme gene RZ106 and RZ135 complementary to two sides bases of the target GUC were synthesized and cloned into the plasmid pEGFP-C1 which has EGFP
cps.org.tw
以上显示的是最相近的搜索结果。 查看全部搜索结果