Role of the CCAAT-binding protein CBF/NF-Y in transcription

SN Maity, B De Crombrugghe - Trends in biochemical sciences, 1998 - cell.com
SN Maity, B De Crombrugghe
Trends in biochemical sciences, 1998cell.com
The CCAAT motif is one of the common promoter elements present in the proximal promoter
of numerous mammalian genes transcribed by RNA polymerase II. CBF (also called NF-Y
and CP1) consists of three different subunits and interacts specifically with the CCAAT motif.
In each CBF subunit, the segment needed for formation of the CBF–DNA complex is
conserved from yeast to human and, interestingly, the conserved segment of two CBF
subunits, CBF-A and CBF-C, are homologous to the histone-fold motif of eukaryotic histones …
Abstract
The CCAAT motif is one of the common promoter elements present in the proximal promoter of numerous mammalian genes transcribed by RNA polymerase II. CBF (also called NF-Y and CP1) consists of three different subunits and interacts specifically with the CCAAT motif. In each CBF subunit, the segment needed for formation of the CBF–DNA complex is conserved from yeast to human and, interestingly, the conserved segment of two CBF subunits, CBF-A and CBF-C, are homologous to the histone-fold motif of eukaryotic histones and archaebacterial histone-like protein HMf-2. The histone fold motifs of CBF-A and CBF-C interact with each other to form a heterodimer that associates with CBF-B to form a heterotrimeric CBF molecule, which then binds to DNA.
cell.com
以上显示的是最相近的搜索结果。 查看全部搜索结果