SVSVGMKPSPRP: a broad range adhesion peptide

E Estephan, J Dao, MB Saab, I Panayotov… - Biomedizinische …, 2012 - degruyter.com
E Estephan, J Dao, MB Saab, I Panayotov, M Martin, C Larroque, C Gergely, FJG Cuisinier
Biomedizinische Technik/Biomedical Engineering, 2012degruyter.com
Background: A combinatorial phage display approach was previously used to evolve a 12-
mer peptide (SVSVGMKPSPRP) with the highest affinity for different semiconductor
surfaces. The discovery of the multiple occurrences of the SVSVGMKPSPRP sequence in an
all-against-all basic local alignment search tool search of PepBank sequences was
unexpected, and a Google search using the peptide sequence recovered 58 results
concerning 12 patents and 16 scientific publications. The number of patent and articles …
Abstract
Background: A combinatorial phage display approach was previously used to evolve a 12-mer peptide (SVSVGMKPSPRP) with the highest affinity for different semiconductor surfaces. The discovery of the multiple occurrences of the SVSVGMKPSPRP sequence in an all-against-all basic local alignment search tool search of PepBank sequences was unexpected, and a Google search using the peptide sequence recovered 58 results concerning 12 patents and 16 scientific publications. The number of patent and articles indicates that the peptide is perhaps a broad range adhesion peptide.
Methods: To evaluate peptide properties, we conducted a study to investigate peptide adhesion on different inorganic substrates by mass spectrometry and atomic force microscopy for gold, carbon nanotubes, cobalt, chrome alloy, titanium, and titanium alloy substrates.
Results: Our results showed that the peptide has a great potential as a linker to functionalize metallic surfaces if specificity is not a key factor. This peptide is not specific to a particular metal surface, but it is a good linker for the functionalization of a wide range of metallic materials.
Conclusion: The fact that this peptide has the potential to adsorb on a large set of inorganic surfaces suggests novel promising directions for further investigation. Affinity determination of SVSVGMKPSPRP peptide would be an important issue for eventual commercial uses.
De Gruyter
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