[HTML][HTML] Personalized cancer vaccines: clinical landscape, challenges, and opportunities

CS Shemesh, JC Hsu, I Hosseini, BQ Shen, A Rotte… - Molecular Therapy, 2021 - cell.com
… of a personalized TCV may be an effective strategy. The choice of target antigen is a
major determinant of immunogenicity … , or by personalized approaches targeting cancer-associated …

[HTML][HTML] Safety and efficacy of personalized cancer vaccines in combination with immune checkpoint inhibitors in cancer treatment

JY Liao, S Zhang - Frontiers in Oncology, 2021 - frontiersin.org
… In conclusion, a potent personalized cancer vaccine with strong immunogenicity, can
diversify the tumor-specific T cell repertoire, activate immune systems, activate robust effective T …

[HTML][HTML] Therapeutic vaccines targeting neoantigens to induce T-cell immunity against cancers

SC Pao, MT Chu, SI Hung - Pharmaceutics, 2022 - mdpi.com
… had stable disease (SD), suggesting that Nous-209 is safe and immunogenic and may …
Another phase I study, ADXS-NEO-2, targeted personalized neoantigens for each cancer patient. …

Abstract CT007: Safety and immunogenicity of a personalized neoantigen-Listeria vaccine in cancer patients

JR Hecht, JW Goldman, S Hayes, D Balli, MF Princiotta… - Cancer Research, 2019 - AACR
Safety and immunogenicity of a personalized neoantigen-Listeria vaccine in cancer patients
[… In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; …

[HTML][HTML] T-cell responses to immunodominant listeria epitopes limit vaccine-directed responses to the colorectal cancer antigen, guanylyl cyclase C

JC Flickinger Jr, J Singh, Y Yarman… - Frontiers in …, 2022 - frontiersin.org
… testing Lm cancer vaccines across a wide variety of cancers, … Here, we assessed the
immunogenicity of an Lm vaccine … trials testing personalized cancer vaccines between 2017 …

Abstract B15: Combination immunotherapy of murine prostate cancer using a Listeria-based PSA vaccine: Immune correlates of efficacy and resistance development

EK Bongiorno, T Baybutt, C Portocarrero, A Snook… - Cancer Immunology …, 2018 - AACR
… responses triggered by tumor vaccines or checkpoint inhibitors. Here we explored the
therapeutic potential of combining radiation therapy (RT) and a prostate cancer vaccine (ADXS-…

[HTML][HTML] Vaccine therapies for cancer: then and now

MA Morse, WR Gwin III, DA Mitchell - Targeted oncology, 2021 - Springer
immunogenic context (a “vaccine”), would, due to the preferential targeting of cancer cells,
enable relatively safe and … in patients with solid tumors showed that personalized neoantigen …

[HTML][HTML] The current state of treatment and future directions in cutaneous malignant melanoma

M Ernst, A Giubellino - Biomedicines, 2022 - mdpi.com
patients demonstrated the safety and immunogenicity of a personal neoantigen long-peptide
vaccine … A study evaluating the feasibility of a similar personal neoantigen vaccine in …

A Review of Clinical Trials Involving Genetically Modified Bacteria, Bacteriophages and Their Associated Risk Assessments

P Gulig, S Swindle, M Fields, D Eisenman - Applied Biosafety, 2024 - liebertpub.com
… Considerable research is being done on using recombinant bacteria as cancer vaccines
to immunize cancer patients against their tumors or to kill the tumor cells directly as oncolytic …