Selective depolarization of the muscle membrane in frog nerve-muscle preparations by a chromatographically purified extract of the dinoflagellate Ostreopsis …
FA Meunier, JA Mercado, J Molgó… - British journal of …, 1997 - ncbi.nlm.nih.gov
FA Meunier, JA Mercado, J Molgó, TR Tosteson, GE de Motta
British journal of pharmacology, 1997•ncbi.nlm.nih.gov… 1 The actions of a chromatographically identified extract of the marine dinoflagellate
Ostreopsis lenticularis, named ostreotoxin-3 (OTX-3), were studied on frog isolated
neuromuscular preparations. 2 OTX-3 (1 ± 10 μg ml71) applied to cutaneous pectoris nerve-muscle
preparations depolarized skeletal muscle fibres and caused spontaneous contractions. The
depolarization was neither reversed by prolonged washing nor by (+)-tubocurarine. …
Ostreopsis lenticularis, named ostreotoxin-3 (OTX-3), were studied on frog isolated
neuromuscular preparations. 2 OTX-3 (1 ± 10 μg ml71) applied to cutaneous pectoris nerve-muscle
preparations depolarized skeletal muscle fibres and caused spontaneous contractions. The
depolarization was neither reversed by prolonged washing nor by (+)-tubocurarine. …
Abstract
1. The actions of a chromatographically identified extract of the marine dinoflagellate Ostreopsis lenticularis, named ostreotoxin-3 (OTX-3), were studied on frog isolated neuromuscular preparations.
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