Severe chronic abuse of zolpidem in refractory insomnia
G Chiaro, A Castelnovo, G Bianco, P Maffei… - Journal of Clinical …, 2018 - jcsm.aasm.org
G Chiaro, A Castelnovo, G Bianco, P Maffei, M Manconi
Journal of Clinical Sleep Medicine, 2018•jcsm.aasm.orgZolpidem is an imidazopyridine nonbenzodiazepine hypnotic drug with a high affinity to the
α1 subunit of the gamma amino butyric acid A receptor It is the first pharmacological option
in the short-term management of sleep-onset insomnia. Initially considered a safer drug
compared to benzodiazepines because of lower liability for abuse and dependence,
recently, an increasing body of reports has questioned zolpidem's proneness to misuse. In
this report, we describe a case of serious zolpidem abuse requiring pharmacological …
α1 subunit of the gamma amino butyric acid A receptor It is the first pharmacological option
in the short-term management of sleep-onset insomnia. Initially considered a safer drug
compared to benzodiazepines because of lower liability for abuse and dependence,
recently, an increasing body of reports has questioned zolpidem's proneness to misuse. In
this report, we describe a case of serious zolpidem abuse requiring pharmacological …
Zolpidem is an imidazopyridine nonbenzodiazepine hypnotic drug with a high affinity to the α1 subunit of the gamma amino butyric acid A receptor It is the first pharmacological option in the short-term management of sleep-onset insomnia. Initially considered a safer drug compared to benzodiazepines because of lower liability for abuse and dependence, recently, an increasing body of reports has questioned zolpidem's proneness to misuse. In this report, we describe a case of serious zolpidem abuse requiring pharmacological washout during hospitalization because of previous withdrawal seizures in a patient with chronic sleep-onset and maintenance insomnia.
Citation
Chiaro G, Castelnovo A, Bianco G, Maffei P, Manconi M. Severe chronic abuse of zolpidem in refractory insomnia. J Clin Sleep Med. 2018;14(7):1257–1259.
American Academy of Sleep Medicine
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