Simvastatin-dependent actin cytoskeleton rearrangement regulates differentiation via the extracellular signal-regulated kinase-1/2 and p38 kinase pathways in rabbit …
Y Han, SJ Kim - European journal of pharmacology, 2018 - Elsevier
Alterations in cell morphology involve changes in the actin cytoskeleton and play crucial
roles in determining chondrocyte phenotypes. Although the effects of simvastatin (SV) have
been demonstrated in various cell types, the mechanisms and effects of SV on chondrocyte
differentiation and actin cytoskeletal rearrangement are still unclear. Here, we investigated
the roles of actin filament rearrangement on SV-induced differentiation of rabbit articular
chondrocytes. Treatment with SV caused actin remodeling in comparison with that in …
roles in determining chondrocyte phenotypes. Although the effects of simvastatin (SV) have
been demonstrated in various cell types, the mechanisms and effects of SV on chondrocyte
differentiation and actin cytoskeletal rearrangement are still unclear. Here, we investigated
the roles of actin filament rearrangement on SV-induced differentiation of rabbit articular
chondrocytes. Treatment with SV caused actin remodeling in comparison with that in …
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